View Original SizeCAS:11470-99-6
Appearance White or almost white powder
Identification Meets the requirements
Specific Rotation -0.10 ~ +0.10°
Water ≤0.5%
Heavy metals ≤0.002%
Redidue in Ignition ≤0.2%
Related Substances Meets the requirements
Benzene Sulfonic Acid 27.3 ~ 28.7%
Ethanol ≤300ppm
Toluene ≤60ppm
Benzene ≤2ppm
Acetic Acid ≤600ppm
Methylamine ≤20ppm
Ethyl Benzene Sulfonate ≤5ppm
Particle Size Meets the requirements
Assay 98.0 ~102.0%
Standard USP33
Solubility:Slightly soluble in water; sparingly soluble in ethanol
Biological Activity:L-type calcium channel blocker that displays antihypertensive properties. Inhibits Ca 2+ -induced contractions in depolarized rat aorta (IC 50 = 1.9 nM) and displays vasoprotective effects in cardiovascular disease. Inhibits proliferation of human vascular smooth muscle cells and epidermoid carcinoma A431 cells (IC 50 = 25 μ M).
Usage:A dihydropyridine calcium channel blocker. Used as an antianginal and antihypertensive
Introduction:
Amlodipine is a medication used to treat high blood pressure andcoronary artery disease.While calcium channel blockers are not typically recommended in heart failure, amlodipine may be used if other medications are not sufficient for high blood pressure or heart related chest pain.Amlodipine is taken by mouth and has an effect for at least a day.
Amlodipine is a long acting calcium channel blocker of the dihydropyridine type. It works partly by increasing the size of arteries.
Amlodipine is on the WHO Model List of Essential Medicines, the most important medications needed in a basic health system.It is available as a generic medication
